جلد 53

P 53 ( Protein 53 kDa )

Protein Description 393 amino acids; 53 kDa phosphoprotein; contains, from N-term to C-term, a transactivation domain, a DNA-binding domain, nuclear localization signals and a tetramerization domain. Expression Widely expressed. Localisation Nucleus. Function Tumour suppressor gene; P53 is a transcriptional regulator acting as a guardian of the genome; in response to DNA damage, p53 is overexpr...

P 53 ( Protein 53 kDa )

پیوستها 53

“ ’ ’ [ 53 . ! a ’ ” ’ ’ ’ ’ ”

The accelerating trend toward Faster, Better, Cheaper (FEE) missions places increasing emphas is on the trade-offs between requirements and risk to reduce cost and development times, while still improving quality and reliability. The Risk/Requirenlents Trade-off Guidelines discussed in this paper are part of an integrated approach to address the main issues by focusing on the sum of prevention,...

Cell p 53

Downlo PIM family of serine threonine protein kinases plays an important role in regulating both the growth and rmation of malignant cells. However, in a cell line–dependent manner, overexpression of PIM1 can t cell and tumor growth. In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 oversion was associated with marked increases in cellular senescence, as shown by changes in the le...

Mole Spo p 53

acrjourna h levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, ting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. t this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two ndent lines of transgenic mice, Mdm4 and Mdm4, developed spontaneous tumors, the most prevf ...